Quinoline-Val-Asp-Difluorophenoxymethylketone
QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone
CAS: 1135695-98-5
Molecular Formula: C26H25F2N3O6
Quinoline-Val-Asp-Difluorophenoxymethylketone - Names and Identifiers
Quinoline-Val-Asp-Difluorophenoxymethylketone - Physico-chemical Properties
| Molecular Formula | C26H25F2N3O6 |
| Molar Mass | 513.49 |
| Density | 1.346±0.06 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 808.9±65.0 °C(Predicted) |
| Solubility | DMSO: 25 mg/mLEthanol: 100 mg/mL (194.75 mM)( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| Appearance | powder |
| Color | white to light brown |
| pKa | 3.92±0.19(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Use | Q-VD-OPh is an irreversible pan-caspase (caspase) inhibitor with high anti-apoptotic ability. The IC50 value of inhibiting caspase 7 is 48 nM, and the IC50 value of inhibiting caspase 1,3,8,9,10,12 is between 25 and 400 nM. Q-VD-OPh can inhibit HIV infection. Q-VD-OPh can penetrate the blood-brain barrier. |
| Target | Caspase-1; Caspase-3; Caspase-8; Caspase-9 |
| In vitro study | Q-VD-OPh (5-100 μm) effectively inhibited the DNA gradient induced by Actinomycin D and the subsequent apoptosis in WEHI 231 cells with little cytotoxicity. Q-VD-OPh prevented caspase-mediated PARP cleavage and activation of the major promoter and effector caspase. Q-VD-OPh protects against Virus-induced cardiomyocyte apoptosis. |
| In vivo study | Q-VD-OPh inhibited caspase-1 activity, IL-18 protein expression, and neutrophil infiltration in ischemic mice. In the in vivo test, Q-VD-OPh by inhibiting the activity of caspase-3, to avoid Virus induced myocardial injury. In the TgCRND8 mouse model, Q-VD-OPh inhibited caspase-7 of activation and inhibited tau-related pathological changes. |
Quinoline-Val-Asp-Difluorophenoxymethylketone - Risk and Safety
| WGK Germany | 3 |
Quinoline-Val-Asp-Difluorophenoxymethylketone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.947 ml | 9.737 ml | 19.475 ml |
| 5 mM | 0.389 ml | 1.947 ml | 3.895 ml |
| 10 mM | 0.195 ml | 0.974 ml | 1.947 ml |
| 5 mM | 0.039 ml | 0.195 ml | 0.389 ml |
Last Update：2024-01-02 23:10:35
Quinoline-Val-Asp-Difluorophenoxymethylketone - Cell Experiment
Caspase inhibitors are added. Viabilityand cell number are determined by Trapan blue exclusion from three random fields of greater than 200 cells/field. All experts are performing a minimum of three times. Cell Line: WEHI-231 cells
Last Update：2023-08-16 21:32:38
Quinoline-Val-Asp-Difluorophenoxymethylketone - Animal Experiment
Animal model: C57BL/6 mice
Last Update：2023-08-16 21:32:38
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Product Name: QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone Visit Supplier Webpage Request for quotationCAS: 1135695-98-5
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Spot supply
Product Name: QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone Visit Supplier Webpage Request for quotationCAS: 1135695-98-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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